小蜜桃觉得人生甚是空虚，在同性恋医生的建议下，她出发前往三藩市，去寻找灵魂的启发，谁缺料陷入了疯狂的开放世界......

　　LIFE ON TOP is a new erotic television series exploring the sex-filled adventures of four young women striving to make it in Manhattan.
　　Sophie, an ambitious but naïve business school graduate who just broke up with her college boyfriend, moves to New York intent on making her mark at a venture capital firm. She's shocked when she arrives at her older sister Bella's fabulous city apartment and discovers that gorgeous, confident and outgoing Bella is also a very successful and much in demand erotic model with plenty of scandalous secrets to reveal. But Bella, who is not as tough as she seems, is also facing the reality of the limited lifespan of her beauty-obsessed profession and yearning for a more stable and meaningful relationship with that one special person.
　　While Sophie is still burdened with some old-fashioned ideas about sexuality, she's also envious of Bella's glamorous, liberated girl-about-town lifestyle. And then there's all those beautiful new people she'll get to meet. There's so much more to learn about life and love from an ever-expanding group of vibrant, sexually-charged girlfriends and the men who hover around them.
　　LIFE ON TOP is based on the upcoming St. Martin's novel by Clara Darling.

　　杰米（杰克•吉伦哈尔 Jake Gyllenhaal 饰）出身医药世家，舌灿莲花，热情似火，是电器行的金牌销售，不过由于桃花运太壮，以至于因为跟女同事在工作时间亲热，被老板开除。此后，他在辉瑞公司连番洗脑后，成为了一名医药销售代表。为了能打开区域市场，他摸清了某医院的底细，决定从主治医师斯坦下手。他用1千美元的支票，换取了一个实习生的身份，穿梭于诊室。某日，他偶然间邂逅了因帕金森症就诊的女患者玛姬（安妮•海瑟薇 Anne Hathaway 饰），并阴差阳错瞥见了她的乳房。正当花花公子以为占了便宜时，却被玛姬抡包打伤，甚至还拍了照片。为了讨回声誉，他利用关系要到了对方号码，并约她面谈。没想到这次约会，却让两人陷入了匪夷所思的亲密关系之中，令他难以自拔。正当杰米因伟哥成为销售红人时，玛姬的病患却每况愈下……